剩余胆固醇对狼性炎中不良结局的影响
Xiaolei Shi1,2, Xinxin Zhang1,2, Yuewen Lu1,2
1Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, 58th, Zhongshan Road II, Guangzhou, 510080, Guangdong, China.
Lipids in health and disease
|April 11, 2025
概括
较高的残留胆固醇 (RC) 水平与狼性炎 (LN) 中脏表现不佳有关. 这表明RC可以成为一个有价值的,非侵入性的预后工具,用于评估LN进展和指导患者管理.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心血管医学 心血管医学
- 免疫学 免疫学 免疫学
背景情况:
- 剩余胆固醇 (RC) 与炎症和病的发展有关.
- 在狼性炎 (LN) 病原和预后中RC的具体作用尚不清楚.
- 了解RC的影响对于管理LN患者和预防并发症至关重要.
研究的目的:
- 调查残留胆固醇 (RC) 水平与狼性炎 (LN) 患者不良结局风险之间的关联.
- 确定RC是否可以作为LN疾病进展的预后生物标志物.
- 根据RC水平对LN患者进行分层,并评估结局风险.
主要方法:
- 在2000年至2018年期间,对909名被诊断患有狼性炎 (LN) 的患者进行了观察性研究.
- 患者被分为较低和较高的RC组,使用最佳切割值为86.88 mg/dL.
- 使用包括卡普兰-梅尔曲线和多变量考克斯回归在内的生存分析来评估脏结果 (血清肌素翻倍,末期脏疾病).
主要成果:
- 在8.33年的中位数随访期间,14.74%的患者经历了不良结局.
- 在LN患者中,较高的RC水平显著与较差结局的风险增加有关 (P < 0.001).
- 多变量分析证实较高的RC作为不良结局的独立预测因素 (HR: 1.98,95% CI: 1.16-3.39).
结论:
- 升高的残留胆固醇 (RC) 水平与狼性炎 (LN) 的不良脏结果有显著的关联.
- RC显示出作为临床评估和LN患者风险分层的非侵入性预后生物标志物的潜力.
- 向RC可能提供一种新的治疗策略,以改善LN的结局.
更多相关视频
08:45LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
Published on: November 17, 2018
13.2K
08:505/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
23.5K
相关概念视频
01:17Factors Affecting Renal Clearance: Renal Impairment
36
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
36
01:11Renal Failure: Dose Adjustments
38
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
38
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents
473
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
473
01:20Renal Corpuscle
1.3K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
1.3K
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
329
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
329
01:33Hormonal Regulation
32.7K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
32.7K