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Updated: May 23, 2025

Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions
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使用一种新的计算工作流来解码SP-D和糖结合机制

Deng Li1, Mona S Minkara1

  • 1Department of Bioengineering, Northeastern University, Boston, Massachusetts.

Biophysical journal
|April 11, 2025
PubMed
概括

计算方法揭示了表面活性蛋白D (SP-D) 如何与病原体甘结合,识别了关键部位和依赖的机制. 这增强了对天生的免疫力的理解,并有助于对抗Pseudomonas aeruginosa等感染的治疗发展.

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相关概念视频

Protein Glycosylation01:25

Protein Glycosylation

Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...
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