相关实验视频
Updated: May 15, 2025

12:59
Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
34.4K
布雷维林A通过调节HSP 70来抑制牛皮中的IL-17A诱导的炎症
Chia-Ling Li1, Kuei-Ying Yeh2, Wen-Nan Huang3
1Children's Medical Center, Taichung Veterans General Hospital, Taichung 407, Taiwan, R.O.C.
Molecular medicine reports
|April 11, 2025
概括
布雷维林A通过增加热冲击蛋白70 (HSP 70) 和减少炎症类细胞因子来减少牛皮的症状. 这种天然化合物通过调节炎症反应,显示出治疗牛皮的潜力.
科学领域:
- 皮肤病学 皮肤病学
- 分子生物学分子生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 牛皮涉及细胞的过度扩散和炎症.
- 热冲击蛋白70 (HSP 70) 家族蛋白质参与蛋白质折叠,压力反应和炎症.
- 准HSP 70为牛皮等炎症性疾病提供了治疗潜力.
研究的目的:
- 研究布雷维林A对IL-17A刺激的HaCaT细胞中HSP70表达和促炎性细胞因子产生的影响.
- 阐明HSP 70在布雷维林A抗炎作用中的作用.
- 在牛皮的小鼠模型中评估布雷维林A对皮肤病理的影响.
主要方法:
- 用IL-17A刺激HaCaT细胞,然后用布雷维林A治疗.
- 使用HSP 70抑制剂来评估其在细胞因子调节中的作用.
- 免疫组织化学和血素和欧染色被用来检查小鼠的皮肤病理.
主要成果:
- 布雷维林A在IL-17A刺激后的HaCaT细胞中降低了IL-6和IL-8水平.
- 布雷维林A在HaCaT细胞中增加了HSP 70和HSP 90的表达.
- 抑制HSP 70逆转了布雷维林A对细胞因子水平的抑制作用.
- 在体内,布雷维林A增强了HSP 70的表达,并减少了皮肤的过度增殖.
结论:
- 布雷维林A调节HSP 70的表达,并减少IL-17A诱导的角质细胞的炎症.
- 布雷维林A的抗炎作用部分通过HSP 70进行介导.
- 布雷维林A证明了作为牛皮的创新治疗剂的潜力.
相关概念视频
T Cell Types and Functions
643
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
643
NF-κB-dependent Signaling Pathway
7.2K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
7.2K
The JAK-STAT Signaling Pathway
8.5K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.5K
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
103
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
103
Inflammatory Response
1.6K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
1.6K
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
91
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
91

