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Updated: May 21, 2025

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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在KDM5C脱离X染色体无活化是由促进者-近端DNA元素驱动的,并由域上下文增强

Samantha Peeters1, Sarah Baldry1, Andrea J Korecki1,2

  • 1Department of Medical Genetics, University of British Columbia, Life Sciences Institute, 2350 Health Sciences Mall,Vancouver, BC, Canada V6T 1Z3.

Human molecular genetics
|April 11, 2025
PubMed
概括

超过20%的X相关基因逃脱了X染色体失活 (XCI). 研究人员确定了人类KDM5C驱动XCI逃逸的2.6kb区域,突出了局部元素和基因拷贝数的重要性.

关键词:
通过DNA甲基化.这就是KDM5C.在X染色体中,X染色体不活化.从X的失活中逃脱出来.基因调节 基因调节 基因调节

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