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断断续续的禁食和维生素E在减轻甲素诱导的甲状腺功能低下症在老鼠模型中的进展中的预防作用
Nirdesh Kumar1, Ashmita Das1, Nidhi Kumari1
1Department of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, India.
The British journal of nutrition
|April 11, 2025
概括
间歇性禁食 (IF) 和维生素E补充剂在降低甲状腺损伤和改善甲状腺功能低下模型中的健康标志物方面显示出有前途. 这些实用干预措施为治疗甲状腺疾病提供了潜在的替代方案.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 代谢疾病 代谢疾病
背景情况:
- 甲状腺疾病是全球普遍存在的代谢生活方式疾病.
- 目前治疗甲状腺功能障碍的方法往往是终身的,昂贵的和不切实际的.
- 间歇性禁食 (IF) 影响生活方式,肠道微生物群和昼夜节律.
研究的目的:
- 为了研究IF与维生素E结合的潜力 (Vit. E) 补充剂可以降低甲状腺疾病的风险.
- 为了评估IF和Vit的抗氧化作用. 在管理甲状腺功能障碍.
- 探索全球甲状腺疾病管理的经济有效和实用的饮食方案.
主要方法:
- 实验动物被分为五组:甲状腺功能良好,甲状腺功能低下控制,IF + Vit. E,Vit. 的意思就是E,Vit. E,和IF. 这两种类型.
- 甲状腺功能低下症被诱导使用propylthiouracil超过24天.
- 如果和Vit. 根据实验组的设计,E (66 mg/ml) 被使用.
主要成果:
- 甲状腺功能低下的动物表现出增加的焦虑,体重增加和脂质过氧化.
- 在甲状腺功能低下模型中观察到甲状腺激素水平,运动运动活性和抗氧化剂水平的显著降低.
- 间歇性禁食和维生素E有效地减轻了实验动物的甲状腺损伤.
结论:
- 如果和Vit. 乙醇补充剂在抵消诱导性甲状腺功能低下的不良影响方面表现出有效性.
- 这些疗法为治疗甲状腺疾病提供了一种有希望,实用且具有成本效益的方法.
- 这项研究将古老的阿育吠陀原则与甲状腺健康管理的现代策略相结合.
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