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Updated: May 15, 2025

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors
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分子动力学模拟显示,R399Q突变破坏了XRCC1-polβ相互作用,可能损害DNA基切除修复途径

Nabajyoti Goswami1, Rupam Dutta2, Rene Barbie Browne3

  • 1Department of Bioengineering and Technology, Gauhati University, Jalukbari, Guwahati, Assam, India.

Journal of biomolecular structure & dynamics
|April 11, 2025
PubMed
概括

在XRCC1中的R399Q突变通过破坏其与DNA聚合酶β的相互作用来破坏DNA修复. 这项分子动力学研究揭示了蛋白质结合的改变,影响了基因组稳定性和癌症风险.

关键词:
基础切除修复的基础切除修复癌症的易感性 癌症的易感性形状的变化 形状的变化主要组件分析的主要组件分析蛋白质蛋白质相互作用

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Application of Laser Micro-irradiation for Examination of Single and Double Strand Break Repair in Mammalian Cells08:18

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