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在治疗期间的HBcrAg动态变化预测了慢性乙型肝炎B患者的HBsAg损失

Ling Ye¹, Wenxian Ouyang², Yingping Gu¹

¹Department of Maternal and Child Health, Xiangya School of Public Health, Central South University, Changsha, China.

Journal of medical virology

|April 11, 2025

概括

在患有慢性乙型肝炎的儿童中,在抗病毒治疗期间乙型肝炎核心相关抗原 (HBcrAg) 的快速下降预测乙型肝炎表面抗原 (HBsAg) 损失,这是功能治愈的关键标志物. 这一发现有助于监测儿科患者的治疗有效性.

科学领域:

肝病学肝病学是一种肝病学.
病毒学病毒学
儿童传染病儿童传染病

背景情况:

乙型肝炎表面抗原 (HBsAg) 损失意味着慢性乙型肝炎 (CHB) 患者的功能治愈.
乙型肝炎核心相关抗原 (HBcrAg) 的动力学及其与接受抗病毒治疗的儿科CHB患者的HBsAg损失的相关性仍未得到充分研究.

研究的目的:

在接受抗病毒治疗的CHB儿童中,研究HBcrAg下降率与HBsAg损失的实现之间的关联.
在儿科CHB患者中确定HBsAg损失的预测因素.

主要方法:

一项前性队列研究,涉及86名未经治疗的儿科CHB患者.
在抗病毒治疗期间计算HBcrAg下降速度,将患者分为快速和缓慢下降组.
分析HBsAg损失作为主要结果,使用Kaplan-Meier和接收器操作特征 (ROC) 曲线.

主要成果:

26.2%的参与者在随访结束时实现了HBsAg损失.
对于HBsAg损失的独立预测因素包括较低的基线HBsAg水平和更快的HBcrAg下降速度 (HR=1.30).
快速下降的HBcrAg组显示,HBsAg损失的累积发病率显著更高,下降的速度有效预测HBsAg损失 (AUC=0.735).

结论:

在抗病毒治疗期间HBcrAg下降的速度是儿科CHB患者HBsAg损失的重要预测因素.
监测HBcrAg动态可以帮助评估CHB儿童功能治愈的可能性.
将HBcrAg下降速度与基线HBsAg水平相结合,可以提高HBsAg损失的预测准确度.

关键词:

现在,CHB已经成为了CHB.这就是HBcrAg.导致HBsAg的损失.降低速度的速度下降.儿科儿科儿科

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