怀孕期和神经发育结果在单独的早产婴儿不到29周的怀孕期
Smita Roychoudhury1, Selphee Tang2, Shabih U Hasan3
1Department of Pediatrics, McMaster University, Hamilton, ON, Canada.
Frontiers in pediatrics
|April 11, 2025
概括
在冬季怀孕的早产 (<29周妊娠) 婴儿表现出较差的认知和语言发育. 这突显了季节性环境因素对高风险婴儿神经发育结果的影响.
科学领域:
- 新生儿研究新生儿研究
- 发育儿科 发育儿科
- 环境健康 环境健康
背景情况:
- 季节性环境变化会影响胎儿的发育.
- 怀孕季对极度早产婴儿神经发育的影响尚不清楚.
研究的目的:
- 调查受孕季节与神经发育结果之间的关联.
- 为了评估怀孕29周之前出生的单体婴儿在18-21个月的校正年龄时的认知,语言和运动技能.
主要方法:
- 在2006年至2015年间出生婴儿的回顾性队列研究.
- 怀孕季节是由出生日期和妊娠年龄决定的.
- 贝利婴儿和幼儿发展尺度,第三版 (贝利-III) 用于神经发育评估.
- 多变量逻辑回归分析调整为混因子.
主要成果:
- 在冬季和非冬季怀孕组之间,复合贝利-III分数没有显著差异.
- 在冬季怀孕的婴儿中,认知能力低 (aOR 2.78) 和语言能力低 (aOR 1.97) 的调整赔率比率显著更高.
- 摩托分数没有显著差异.
结论:
- 冬季怀孕与极度早产婴儿的认知和语言结果较差有关.
- 研究结果表明,季节性环境因素在神经发育中可能发挥作用.
- 建议在更大,更多样化的队列中进一步验证.
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