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败血症作为老年癌症患者死亡的原因:更新的SEER数据库分析2000-2021年
Ibrahim Ellaithy1,2, Hind Elshiekh3, Safia Elshennawy4
1Faculty of Medicine, Cairo University Kasr Alainy, Cairo, Egypt.
Annals of medicine and surgery (2012)
|April 11, 2025
概括
败血症对老年癌症患者构成重大死亡风险,特别是在诊断后的第一年内. 胃癌和肝癌等特定癌症显示出与败血症相关的死亡率增加,突出了针对性感染控制的需要.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 老年病的医生 老年病的医生
背景情况:
- 败血症是对感染的危及生命的反应,对老年癌症患者来说,由于免疫力受损和并发症,这是一个重大挑战.
- 这一群人群特别容易受到与败血症相关的死亡率的影响,因此需要更新证据以改善临床管理.
研究的目的:
- 评估与老年癌症患者的败血症相关的死亡风险.
- 提供当前数据,为管理这种脆弱人群的败血症策略提供信息.
主要方法:
- 利用了来自监测,流行病学和最终结果 (SEER) 计划 (2000-2021) 的数据.
- 对因败血症死亡的老年癌症患者计算的标准化死亡率 (SMR) 和过度风险 (ER).
- 根据随访时间和癌症类型分析死亡率数据.
主要成果:
- 在5,239,194名老年癌症患者中,18,311人死于败血症.
- 整体败血症死亡率显示显著的SMR (O/E=1.32),在诊断后的第一年内风险明显增加 (O/E=3.00).
- 胃 (O/E=2.55) 和肝/肝内胆道癌 (O/E=5.56) 呈现出与败血症相关的死亡风险增加.
结论:
- 败血症仍然对老年癌症患者构成威胁,尽管随着时间的推移死亡率下降.
- 癌症治疗的免疫抑制和抗生素耐药性增加有助于这种风险.
- 加强感染控制和专注的医疗保健策略对于这个患者群体至关重要.
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