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口腔微生物组的组成与怀孕期间的抑郁症状有关

Oryan Agranyoni¹, Treva Rowley¹, Sara B Johnson^2,3

¹Stanley Division, Department of Pediatrics, Johns Hopkins School of Medicine, USA.

Brain, behavior, & immunity - health

|April 11, 2025

概括

口腔微生物组可能与产前抑郁症有关. 患有抑郁症症状的女性表现出某些细菌的水平较低,这表明母亲心理健康的潜在生物标志物.

科学领域:

微生物组研究的研究.
母亲心理健康母亲心理健康
口腔健康口腔健康

背景情况:

口腔微生物组失调与系统性炎症性疾病有关.
口腔微生物组与产前抑郁症之间的关联还没有得到充分研究.

研究的目的:

调查唾液微生物组组成和怀孕期间抑郁症状之间的关系.
为了确定产前抑郁症的潜在微生物生物标志物.

主要方法:

在PREDICT队列中的400名孕妇的唾液样本使用16SrRNA测序进行了分析.
该研究评估了微生物组组成与抑郁症状的连续 (CES-D尺度0-60) 和分类 (CES-D>16) 测量之间的关联.

主要成果:

抑郁症状 (CES-D ≥16) 与9种细菌种群的丰度显著降低有关,包括*Neisseria*.
较低水平的menaquinol生物合成路径,ectoine生物合成和d-glucarate降解与抑郁症状有关.
结果独立于BMI,吸烟,使用抗生素,口腔健康和妊娠周.

结论:

口腔微生物组显示出与产前抑郁症的潜在关系.
微生物组测量可以作为孕产妇心理健康的有希望的生物标志物.
需要进一步的纵向研究来了解怀孕期间口腔微生物组的时间动态.

关键词:

抑郁症的症状抑郁症的症状尼塞利亚尼塞利亚Neisseria 口腔微生物组是口腔的微生物组.怀孕怀孕怀孕怀孕吸烟吸烟吸烟吸烟三个月的三个月.

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