母亲心理健康障碍与孩子的喘有关:一个基于登记的研究
Eetu P Kanerva1, Minna M Lukkarinen2, Marika H Leppänen3
1Department of Adolescent Psychiatry, University of Turku and Turku University Hospital, Finland.
产前和产后母亲的心理健康障碍与孩子患喘有关. 这种关联在非过敏性喘中更为强烈,这表明早年规划会影响呼吸系统健康.
科学领域:
- 围产期心理健康问题
- 儿科呼吸系统医学 儿科呼吸系统医学
- 流行病学 流行病学
背景情况:
- 母亲周产期精神健康障碍被认为是导致儿童喘发展的因素.
- 了解与儿童喘有关的母亲心理健康问题的时间对于早期干预至关重要.
研究的目的:
- 调查分娩期间产妇精神健康障碍 (MMHD) 与儿童非过敏和过敏喘风险之间的关联.
- 探索MMHDs对后代不同喘表型的影响.
主要方法:
- 一项大规模的队列研究使用了芬兰2001-2006年的医疗保健登记册,包括超过31万名儿童和23万名母亲.
- 在产前一年和产后三年,使用ICD-10代码 (F00-F99) 确定了母亲的精神健康障碍.
- 根据诊断码,儿童喘 (7-12岁) 被分为过敏 (J45.0) 和非过敏 (J45.1) 类型.
主要成果:
- 在母亲心理健康障碍和儿童喘之间发现了显著的关联 (aOR 1.24,95% CI 1.16-1.33).
- 与过敏性喘 (aOR 1.17,95% CI 1.05-1.30) 相比,母亲的精神健康障碍与非过敏性喘 (aOR 1.37,95% CI 1.18-1.60) 的相关性更强.
- 其他重大风险因素包括怀孕期间吸烟,家族喘病史,母亲的职业和孩子的性别.
结论:
- 围产期和生命早期的母亲精神健康障碍与儿童喘风险增加有关.
- 这些发现支持子宫内和生命早期编程影响儿童对呼吸系统疾病的易感性的假设.
- 这些结果强调了母亲心理健康对儿童呼吸系统健康结果的重要性.
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