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Introduction to the Human Microbiota

Introduction to the Human Microbiota

Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity, and disease...

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Updated: Jun 19, 2026

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

Published on: August 30, 2016

在3D生物电子平台中模拟人类肠道微生物群相互作用.

Chrysanthi-Maria Moysidou¹, Douglas C van Niekerk¹, Verena Stoeger¹

¹Department of Chemical Engineering and Biotechnology University of Cambridge Cambridge CB3 0AS UK.

|April 11, 2025

概括

这项研究引入了一个新的生物电子平台来建模人类肠道微生物群,揭示了细菌和后生物如何影响肠道屏障的完整性. 这项技术为研究宿主微生物相互作用和选潜在疗法提供了一种新方法.

关键词:

3D细胞模型 3D细胞模型屏障的完整性屏障的完整性生物电子学生物电子学我们的肠道微生物组.主体与微生物的相互作用.器官在芯片上的器官后生物学的后生物.

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Last Updated: Jun 19, 2026

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

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科学领域:

生物医学工程生物医学工程
微生物学微生物学
胃肠病学胃肠病学

背景情况:

肠道微生物组显著影响宿主健康,影响消化,新陈代谢和神经炎症等疾病.
了解宿主微生物组交叉交谈机制至关重要,但由于传统动物模型的局限性而具有挑战性.
将动物模型的发现转化为人类系统仍然是生物医学研究中的一个重大障碍.

研究的目的:

开发和利用一种生物电子平台,即e-transmembrane,用于创建一个3D人类肠道模型.
研究微生物群,特别是后生物和活细菌对肠道屏障完整性和功能的影响.
建立一个生理上相关的人类模型,用于选治疗和饮食干预措施.

主要方法:

使用e-transmembrane生物电子平台建立一个3D人类肠道模型.
通过电化学阻抗光谱在24小时内在线监测宿主微生物交叉对话.
使用显微镜和分子生物标志物量化验证细菌干预效应.

主要成果:

通过e-transmembrane平台,随着时间的推移,成功地监测了不同的宿主-微生物相互作用模式.
观察到后生物和活细菌对肠道屏障形态和功能的不同影响.
显微镜和生物标记分析证实了不同细菌干预对宿主组织的不同影响.

结论:

电子转膜平台提供了一个强大的工具,用于在与人类相关的背景下研究宿主微生物群相互作用.
这种生物工程模型促进了对肠道健康的后生物和益生菌等干预措施的评估.
开发的框架可以更好地选候选药物和治疗肠道相关疾病的治疗策略.