在昼夜节律障碍中对肠道微生物群的多omics评估:一个横截面的临床研究
Yuting Tian1, Rong Zhao1, Shili Xiao1
1Department of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Frontiers in cellular and infection microbiology
|April 11, 2025
概括
循环节律障碍会破坏肠道微生物群和新陈代谢,恶化临床症状. 了解这些肠道微生物组和代谢物变化可能会导致对昼夜节律障碍的个性化治疗.
科学领域:
- 微生物组研究的研究.
- 代谢学 代谢学 代谢学
- 时间生物学 时间生物学
背景情况:
- 主体的昼夜节律显著影响主体微生物群的相互作用.
- 由于昼夜节律障碍,肠道微生物群和代谢物的具体变化仍然在很大程度上是未知的.
研究的目的:
- 调查昼夜节律障碍,肠道微生物群组成和代谢物概况之间的关系.
- 探索临床症状与这些生物变化之间的相关性.
主要方法:
- 这是一项涉及72名参与者的横截面研究.
- 便DNA的宏基因组测序分析.
- 广泛针对便,尿液和血液的代谢分析.
主要成果:
- 在昼夜节律障碍和胃肠道症状之间观察到积极的相关性.
- 19种肠道微生物物种和各种代谢物被确定为改变的.
- 胆酸相关代谢物与特定的肠道细菌有显著的关联,包括*Lachnospiraceae细菌*和*Streptococcus mitis oralis pneumoniae*.
结论:
- 昼夜节律障碍的临床表现的严重程度与微生物群和新陈代谢的改变有关.
- 未来针对特定微生物或代谢物的个性化干预可以缓解与昼夜节律障碍相关的症状.
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