带有阳性TPOAb的孕妇中甲状腺功能正常的脂质差异及其与临床参数的相关性
Xinxin Chen1, Yuxin Qin1, Qingyao Wang1
1Department of Endocrinology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China.
Frontiers in endocrinology
|April 11, 2025
概括
有阳性甲状腺过氧化酶抗体 (TPOAb) 的孕妇表现出明显的脂质样本,可能会影响怀孕结果. 需要进一步的研究来探索这些改变的脂质分子作为生物标志物.
科学领域:
- 产科和妇科 产科和妇科
- 内分泌学 在内分泌学.
- 代谢学 代谢学 代谢学
背景情况:
- 怀孕期间的亚临床和临床甲状腺功能低下症与脂质障碍和不良结果有关.
- 隔离的阳性甲状腺过氧化酶抗体 (TPOAb) 是一个潜在的危险因素,但其对脂质代谢的影响尚不清楚.
研究的目的:
- 在怀孕早期,检查甲状腺功能良好的孕妇的脂质概况,这些孕妇在怀孕早期有单独的阳性TPOAb.
- 分析改变的脂质样本和甲状腺功能参数之间的相关性.
主要方法:
- 非向液体色谱-质谱 (LC-MS) 用于血清样本的脂质学分析.
- 部分最小平方区分分析 (PLS-DA) 和KEGG途径分析以确定差异性脂质.
- 相关性分析将脂质分子与TPOAb标位等临床参数联系起来.
主要成果:
- 确定了1238个脂质分子;在TPOAb阳性和健康的孕妇之间发现了202个差异性脂质.
- 不同表达的脂质参与多种代谢途径.
- 与TPOAb标位,sCD40L和残留胆固醇相关的特定溶解酸胆 (LPC) 和酸胆 (PC).
结论:
- 与健康对照组相比,带有隔离的TPOAb的甲状腺孕妇表现出明显不同的脂质配置.
- 改变的脂质分子可以作为潜在的生物标志物,在这个人群中产生不良妊娠结果.
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