在接受免疫治疗期间接受息性辐射治疗的患者的前性研究
Georgia Harris1,2, Andrew Bang1,3, Rebecca K S Wong1
1Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Department of Radiation Oncology, University of Toronto, Ontario, Canada.
Advances in radiation oncology
|April 11, 2025
概括
息性放射治疗 (RT) 与免疫疗法相结合对于晚期癌症患者是安全的,没有增加毒性. 患者报告的结果在护理人员的协助下得到改善,这有助于收集数据.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 免疫治疗是一种免疫疗法.
背景情况:
- 息性放射治疗 (RT) 对于管理晚期癌症症状至关重要.
- 同时免疫治疗越来越多地用于晚期癌症.
- 将息性RT与免疫治疗相结合的安全性和有效性需要研究.
研究的目的:
- 为了前性地评估接受免疫治疗的患者的息性RT的安全性和结果.
- 在这种组合模式下评估毒性,治疗反应和患者报告的结果 (PROs).
主要方法:
- 一项前性观察性研究包括39名晚期癌症患者,在28天内接受息性RT和免疫治疗.
- 收集的数据包括基线和随访时的人口统计,RT细节和PRO (埃德蒙顿症状评估量表).
- 主要结局是3个月的毒性;次要结局包括RECIST v1.1反应和PRO合规性.
主要成果:
- 从联合治疗中没有观察到3级或更高的毒性.
- 现场瘤反应 (RECIST v1.1) 在3个月后观察到54%的可评估患者.
- 护理人员辅助的PRO采集改善了合规性,32-41%的患者使用了这种方法.
结论:
- 息性RT在与免疫疗法结合时是安全的,而不会增加毒性.
- 在照射体积之外观察到的反应与单独的免疫疗法相当.
- 护理人员的参与提高了PRO数据收集在这个患者群体中的可行性.
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