单剂量与长期抗生素预防氏素用于跨直肠前列腺活检:单中心前性,随机化,受控试验
Ádám M Fehér1, Zoltán Bajory1, Nándor Czimbalmos1
1Department of Urology, University of Szeged, Szeged, Hungary.
Prostate international
|April 11, 2025
概括
在前列腺活检前,单剂量氏菌素对预防感染与长期预防一样有效. 这种单剂量治疗方案为跨直肠前列腺活检抗生素预防提供了一个理想的选择,具有更好的生态影响.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 跨直肠前列腺活检需要抗生素预防.
- 诺基诺抗生素在欧盟受到限制.
- 斯福米-米是一种潜在的替代品,但最佳剂量尚未确定.
研究的目的:
- 为了评估单剂量与长期氏-胺预防的疗效和安全性,用于跨直肠前列腺活检.
- 在这种情况下,要确定福米-托美塔摩尔的理想剂量和施用时间.
主要方法:
- 对204名接受前列腺活检的患者进行前性随机研究.
- 手臂A:手术前一个小时单剂量胺-胺.手术前一个小时.
- 手臂B:单剂量斯福米辛-托梅塔摩尔加上第二剂48小时后手术.
主要成果:
- 无症状细菌性尿病,症状性尿路感染或发烧性尿路感染在两组之间没有显著差异.
- 在长期预防组 (B组) 中,血的发生频率更高.
- 医院住院和死亡率在两支部队之间是相似的.
结论:
- 单剂量斯福米辛-托梅塔摩尔对预防感染并发症的长期预防没有劣势.
- 建议使用一次性活检前剂量,以确保其有效性和减少生态影响.
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