多发性硬化症患者中的频率:系统性审查和元分析
Saeed Vaheb1, Danial Dehghani Firouzabadi2, Hamed Ghoshouni1
1Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Clinical parkinsonism & related disorders
|April 11, 2025
概括
震影响了三分之一的多发性硬化症患者,影响了他们的生活质量. 这一系统性审查强调了需要有针对性的干预措施来管理PwMS中的震.
科学领域:
- 神经学 神经学
- 神经退行性疾病 神经退行性疾病
- 临床研究 临床研究
背景情况:
- 多发性硬化症 (MS) 是一种慢性神经退行性疾病.
- 是MS (PwMS) 患者常见和致残的症状.
- 之前对PwMS中震频率的估计差异很大.
研究的目的:
- 系统地审查和估计MS患者的震总频率.
- 为临床和研究目的提供震流行率的可靠估计.
主要方法:
- 在主要数据库 (PubMed/MEDLINE,Embase,Scopus,Web of Science) 进行了系统的搜索,截至2024年4月27日.
- 14项涉及17458名PwMS的研究被纳入了元比例分析.
- 一个随机效应模型被用来计算聚合的震频率及其95%置信区间 (CI).
主要成果:
- 在PwMS中,震的总体汇总频率为33.32% (95%CI:23.47%44.88%).
- 在200多名参与者 (22.46%) 的研究中,震的患病率明显低于200名参与者以下的研究 (47.65%).
- 在各个研究中观察到很高的异质性 (I2 = 98%).
结论:
- 是一个非常普遍的症状,在很大一部分患有MS的人群中经历过.
- 这些发现强调了开发和实施针对PwMS震管理的有针对性的干预措施的重要性.
- 可能需要进一步的研究来探索导致震发病率估计异质性的因素.
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