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Updated: May 14, 2025

Generation of Human Chimeric Antigen Receptor Regulatory T Cells
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通过跨膜域优化改进CAR内部化和循环利用,减少CAR-T细胞因子的释放和耗尽

Shufeng Xie1,2, Jinlan Long3, Ruiheng Wang1,2

  • 1Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Frontiers in immunology
|April 11, 2025
PubMed
概括

优化嵌合式抗原受体T (CAR-T) 细胞的跨膜域可以提高它们的抗瘤疗效. 这种修改减少了CAR-T细胞耗尽和细胞因子释放综合征,改善了B细胞白血病的治疗结果.

关键词:
汽车-t-t是什么意思细胞因子释放细胞因子释放疲 疲 疲 疲 疲在内部化,内化.回收回收是回收的方法.跨膜域域是一个跨膜域.

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