高血压参与者的联合风险因素控制程度和过早死亡率
Jian Zhou1,2,3,4, Minghao Kou2, Rui Tang2
1Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha 410011, China.
Precision clinical medicine
|April 11, 2025
概括
控制多种风险因素可以显著降低高血压患者过早死亡的风险. 对六个或更多因素的最佳控制可以消除高血压.
科学领域:
- 心血管健康 心血管健康
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 高血压是导致过早死亡的主要危险因素.
- 与高血压相关的过度死亡风险需要对缓解策略进行调查.
研究的目的:
- 确定主要心血管风险因素的联合控制是否可以减少或消除高血压患者过度过早死亡风险.
主要方法:
- 一项大型队列研究 (英国生物库) 涉及70,898名高血压患者和224,069名匹配的非高血压参与者,从2006年至2022年进行了跟踪.
- 基于血压,BMI,腰围,LDL胆固醇,HbA1c,白蛋白尿,吸烟和身体活动的关节风险因素控制的评估.
- 考克斯的比例危险模型被用来分析风险因素控制和过早死亡之间的关联.
主要成果:
- 每一个额外的受控风险因素都与早逝风险 (所有原因,癌症,心血管疾病和其他) 的显著降低有关.
- 最佳控制 (≥6个因素) 与全因死亡率降低55%和心血管疾病死亡率降低67%的风险有关.
- 与非高血压对照组相比,高血压患者实现了对关键风险因素的最佳控制,但没有显示过多的死亡风险.
结论:
- 对心血管风险因素的联合控制表明,高血压患者的剂量反应关系与早逝率的降低有关.
- 实现对多种风险因素的最佳控制可以有效消除因高血压而导致的过度死亡风险.
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