素:一种具有多种动脉样硬化机制的天然产品
Chanjun Wan1,2, Qingzhi Liang3, Yirong Ma4
1Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China.
Frontiers in pharmacology
|April 11, 2025
概括
素是一种植物衍生的黄类化合物,在治疗动脉样硬化症 (AS) 中显示出显著的潜力. 本综述详细介绍了它对血管细胞和AS风险因素的有益影响,支持其作为安全治疗剂的发展.
科学领域:
- 生物化学和药理学 生物化学和药理学
- 心血管研究研究心血管研究
- 自然产品化学 自然产品化学
背景情况:
- 动脉样硬化 (AS) 是一种进展性动脉疾病,其全球发病率和死亡率正在增加.
- 目前的AS治疗有局限性,包括不良影响和长期使用的担忧.
- 来自植物的天然化合物正在成为AS的有希望的治疗候选者.
研究的目的:
- 综合审查黄素 (一种植物衍生的黄胺) 的抗动脉样硬化作用.
- 评估黄素对血管细胞和关键AS风险因素的影响.
- 提供关于黄素在AS的临床应用和机制研究的证据.
主要方法:
- 在实验性动脉样硬化模型中对白素的影响进行临床前研究的综述.
- 对黄素对内皮细胞,血管光滑肌细胞,巨细胞和中性粒细胞的调节作用的分析.
- 评估黄素对高血压,高血糖和脂质失调的影响.
主要成果:
- 氨酸对AS涉及的血管细胞具有显著的保护作用.
- 氨酸对主要的AS风险因素具有监管影响.
- 临床前数据支持黄素在动脉样硬化治疗中的治疗潜力.
结论:
- 氨酸是开发新,安全和有效的抗动脉样硬化疗法的有前途的天然化合物.
- 对于临床转化,需要进一步研究黄素的作用机制.
- 氨酸为动脉样硬化心血管疾病的现有治疗提供了潜在的替代方案或补充.
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