相关实验视频
Updated: May 14, 2025

08:40
Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
6.9K
肠道微生物群和表观遗传:对IBD发展的影响
Xue Guo1,2, Jianhong Li1,2, Jing Xu1,2
1Department of Gastroenterology and Hepatology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, China.
Gut microbes
|April 11, 2025
概括
炎症性肠病 (IBD) 涉及肠道微生物群和表观遗传学受饮食的影响. 了解这些相互作用对于开发新的IBD治疗方法至关重要.
科学领域:
- 胃肠道学和免疫学
- 微生物组研究 微生物组研究
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 炎症性肠病 (IBD),包括克罗恩氏病和性结肠炎,是一个重大的全球健康挑战.
- 环境和饮食因素显著塑造肠道微生物群,影响宿主免疫反应和IBD病原体.
- 新兴研究强调了在IBD中微生物代谢物和宿主表观遗传之间的复杂联系.
研究的目的:
- 审查肠道微生物群,表观遗传学和IBD病变的环境/饮食因素之间的复杂相互作用.
- 强调多学科技术在阐明IBD内的宿主-微生物相互作用中的作用.
- 提出一个框架,用于开发IBD的新型治疗策略.
主要方法:
- 文献综述和综合目前关于IBD,肠道微生物群和表观遗传学的研究.
- 对基因组学和代谢学研究的发现进行分析.
- 对表观遗传机制的讨论,包括DNA甲基化,基因素修饰,乳基化,糖基化和非编码RNA.
主要成果:
- 肠道微生物群的组成及其代谢副产品与表观遗传修饰 (DNA甲基化,基因素甲基化,乳基化,糖基化,非编码RNA) 有动态联系.
- 这些宿主-微生物-表观遗传相互作用是IBD基础的复杂病理过程的组成部分.
- 多主题方法对于全面了解这些相互作用至关重要.
结论:
- 肠道微生物群,表观遗传学和环境因素的复杂相互作用是IBD发展的核心.
- 针对这些宿主-微生物-表观遗传轴为创新的IBD疗法提供了有希望的途径.
- 多omics技术为剖析这些复杂的相互作用和推进IBD治疗策略提供了必不可少的工具.
相关概念视频
Anatomy of the Intestines
70.7K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
70.7K
Irritable Bowel Syndrome I: Introduction
207
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
207
Inflammatory Bowel Disease I: Ulcerative Colitis
98
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
98
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
251
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
251
Inflammatory Bowel Disease II: Crohn's Disease
130
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
130
Bacterial Flora of the Large Intestine
362
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
362

