相关实验视频

Updated: May 14, 2025

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.

Published on: February 14, 2021

椎间盘的炎症和止痛特征:与神经缺陷相关的变化

B Morkoç¹, O Aktan², H S Solak²

¹Department of Physical Medicine and Rehabilitation, Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey.

Nigerian journal of clinical practice

|April 11, 2025

概括

这项研究表明,腰椎间盘患者的神经缺陷与特定的炎症生物标志物变化相关. 这些发现表明,针对炎症的潜在新治疗策略可以改善患者的治疗结果.

科学领域:

生物化学生物化学
免疫学免疫学免疫学
神经学神经学

背景情况:

腰椎间盘涉到机械和生化过程,导致神经压缩,炎症和疼痛.
椎间盘的炎症过程因疼痛持续时间,类型和严重程度而异,但与神经系统缺陷的联系尚不清楚.

研究的目的:

为了比较腰椎间盘患者和没有神经缺陷 (WND/WOND) 的特定生物标志物的血清水平与健康对照.
研究的生物标志物包括TNF-α,IL-6,IL-4,IL-1β,β-endorphin,安南胺和2-AG.

主要方法:

从37名WND患者,37名WOND患者和35名健康个体收集了血清样本.
生物标志物水平使用商业酶相关免疫吸收试验 (ELISA) 套件量化.

主要成果:

在所有组中都没有观察到TNF-α水平的显著差异.
与对照组相比,腰椎间盘 (WOND和WND) 的患者显示IL-1β和IL-4的增加.
在WND组,IL-6水平低于对照组;β-endorphin,anandamide和2-AG水平没有显著差异.

结论:

这项研究是首次将腰椎间盘的神经学缺陷与血清生物标志物概况联系起来.
细胞因子水平的变化表明的潜在回归,即使有神经缺陷.
结果强调了需要新的治疗方案,以准腰椎间盘的炎症级联.

关键词:

这是一种β-endorphin.细胞因子细胞因子这是内分泌大麻素 (endocannabinoids) 的作用.这是一种炎症炎症炎症炎症.椎间盘间的椎间盘,椎间盘间的椎间盘.腰部疼痛腰部疼痛腰部疼痛

更多相关视频

Full-Endoscopic Isolation Zone Technique for the Treatment of Lumbar Disc Herniation

Full-Endoscopic Isolation Zone Technique for the Treatment of Lumbar Disc Herniation

Published on: April 7, 2023

Transtubular Endoscopic Posterolateral Decompression for L5-S1 Lumbar Lateral Disc Herniation

Transtubular Endoscopic Posterolateral Decompression for L5-S1 Lumbar Lateral Disc Herniation

Published on: October 14, 2022

相关概念视频

Local Anesthetics: Clinical Application as Epidural Anesthesia

Local Anesthetics: Clinical Application as Epidural Anesthesia

Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...

Local Anesthetics: Adverse Effects

Local Anesthetics: Adverse Effects

While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...