急性胃肠炎是儿童肠脑相互作用障碍发展的危险因素
Aishwarya Palorath1, Claire Narang2, Lourdes Forster3
1Division of Pediatric Gastroenterology, Hepatology and Nutrition, University of Miami, Miller School of Medicine, Miami, Florida, USA.
The American journal of gastroenterology
|April 11, 2025
概括
患有急性胃肠炎 (AGE) 的儿童患肠-大脑相互作用 (DGBIs) 障碍的风险更高. AGE症状的严重程度与患上后感染性DGBI (PI-DGBI) 的可能性增加直接相关.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 肠-大脑轴研究研究
- 传染病流行病学 传染病流行病学
背景情况:
- 急性胃肠炎 (AGE) 是成年人肠脑相互作用障碍 (DGBI) 的常见前体,称为后感染性DGBI (PI-DGBI).
- 关于儿童群体PI-DGBI发育的发病率和风险因素的数据有限.
- 本研究探讨了AGE和儿童DGBI发育之间的联系.
研究的目的:
- 确定AGE是否使儿童易于发展DGBIs.
- 评估AGE严重程度与儿童DGBI后续发展之间的关联.
主要方法:
- 采用了前性,受控的队列研究设计.
- 最近患有AGE的儿童 (病例) 和他们的兄弟姐妹 (对照) 被跟踪了六个月.
- 用基于罗马标准的QPGS IV验证问卷来评估肠-大脑相互作用的障碍.
主要成果:
- 三个月后,20.4%的AGE儿童患有DGBI,而对照组的儿童只有1.8% (P=0.00).
- 在没有DGBI病史的人群中,12.2%的病例患有DGBI,对照人群为0% (P=0.01).
- AGE症状的严重程度与PI-DGBI发展有显著的相关性 (ρ=0.707,P=0.00).
结论:
- 患有急性胃肠炎的儿童患DGBI的可能性明显更高.
- 急性胃肠炎的严重程度是与儿童PI-DGBI发展相关的关键风险因素.
相关概念视频
Other Disorders of Digestive System
641
The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
641
Irritable Bowel Syndrome I: Introduction
213
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
213
Anatomy of the Intestines
71.2K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.2K
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
106
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
106
Gastrointestinal Motility Disorders
235
Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
235
Neural Regulation
39.0K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.0K


