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瘤微环境响应性聚合物输送平台用于癌症治疗

Yiqi Shi¹, Qianqian Yu¹, Lijie Tan²

¹Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Shanghai Key Laboratory of Functional Materials Chemistry, Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, P.R. China.

Angewandte Chemie (International ed. in English)

|April 11, 2025

概括

响应刺激的聚合物输送平台,利用瘤微环境 (TME),增强抗癌药物输送和生物成像. 这些对TME响应的系统可以提高准精度,减少对健康组织的损伤.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
在瘤学瘤学.

背景情况:

化疗药物和生物成像药物通常具有较差的生物可用性,有限的生物相容性和缺乏特定向性.
这导致抗癌疗效降低,诊断成像不准确,在癌症治疗中构成重大挑战.

研究的目的:

审查利用瘤微环境 (TME) 的刺激反应性聚合物输送平台的最新进展.
分析这些平台的分子设计和响应机制.
总结它们在药物输送和癌症诊断成像中的应用.

主要方法:

对TME响应性聚合物输送系统的综合文献综述.
对响应pH,活性氧物种 (ROS),谷氨 (GSH),酶和缺氧的平台进行分析.
检查分子设计,响应机制和生物应用.

主要成果:

响应TME的聚合物平台可在瘤部位控制释放治疗和诊断剂.
这些系统提高了向特异性,提高了抗癌治疗的有效性和成像精度.
它们还可以最大限度地减少对健康组织的损伤,并减少来自非特定药物泄漏的虚假成像信号.

结论:

响应TME的聚合物输送平台是克服传统癌症治疗和诊断局限性的有希望的策略.
对分子和矢量设计的进一步研究对于优化它们的性能至关重要.
这些平台为准确瘤学的未来进步带来了巨大的潜力.

关键词:

癌症的诊断和治疗方法毒品的交付和释放和释放.聚合物矢量设计的设计响应性的分子设计.瘤微环境响应的链接器

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