使用阿巴洛帕拉提德和特里帕拉提德实现骨矿物质密度治疗目标的概率
Felicia Cosman1, Bruce H Mitlak2, Yamei Wang3
1Columbia University College of Physicians and Surgeons, New York, NY, United States.
概括
用阿巴洛帕拉提德或特里帕拉提德治疗骨质疏松症可以改善女性的骨矿物质密度 (BMD) T-分数超过-2.5. 用阿巴洛帕拉提德接着阿伦德罗纳酸的连续治疗进一步提高了超过3.5年的BMDT分数.
科学领域:
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
- 药理学 药理学是指药理学的学科.
背景情况:
- 骨质疏松症治疗的目的是提高骨矿物质密度 (BMD) T-score超过-2.5以减少骨折风险.
- 许多患有骨质疏松症的女性基线T-score低于-2.5,需要有效的治疗策略.
研究的目的:
- 评估在患有骨质疏松症的妇女中实现治疗性BMDT-score (> -2.5) 的概率.
- 为了比较阿巴洛帕拉提德和特里帕拉提德在18个月的疗效和连续的阿巴洛帕拉提德/阿伦德罗纳特治疗在3.5年的疗效.
主要方法:
- 对ACTIVE和ACTIVExtend试验的后期分析,涉及2463名患有骨质疏松症的妇女.
- 后勤回归用于预测T-score在整个部 (TH) 和腰椎 (LS) 的改善.
主要成果:
- 在18个月的时间里,超过50%的女性通过阿巴洛帕拉提德或特里帕拉提德获得了THT得分>-2.5,即使基线T得分低至-2.7.
- >50%通过阿巴洛帕拉提德 (基线T评分 -3.3) 或特里帕拉提德 (基线T评分 -3.2) 实现了LST得分> -2.5.
- 在3.5年的时间里,连续的阿巴洛帕拉提德/阿伦德罗纳特治疗预测了T-score> -2.5的>50%的实现,对于基线THT-score ≥ -2.9和LS T-score ≥ -3.5.
结论:
- 阿巴洛帕拉提德和特里帕拉提德在改善骨质疏松症妇女的BMDT分数方面是有效的.
- 用阿巴洛帕拉提德 (abaloparatide) 连续治疗,然后用阿伦德罗纳酸 (alendronate) 提供持续的BMD改善.
- 基线 BMD 和预测的 T-score 成绩应指导高风险患者的骨质疏松症治疗决策.
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