优化风险因素,以指导在韩国婴儿中使用帕利维祖马布的成本效益
Ji-Man Kang1,2, Xavier Carbonell-Estrany3, Bosco Paes4
1Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, South Korea.
概括
与当前的指南相比,国际风险评分工具 (IRST) 显著改善了韩国婴儿呼吸道同胞性病毒 (RSVH) 住院预测和成本效益. 这种工具为脆弱的婴儿提供了更好的保护,并优化了预防的向.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 卫生经济学 卫生经济学
背景情况:
- 在32-35周妊娠年龄 (wGA) 中出生的韩国婴儿在特定条件下有资格接受帕利维祖马布预防性治疗,以防止呼吸道同胞细胞病毒 (RSVH) 住院治疗.
- 目前韩国针对预防向的指导方针正在评估其有效性.
研究的目的:
- 评估在韩国实施国际风险评分工具 (IRST) 对帕利维祖马布预防向治疗的影响.
- 将IRST的准确性和成本效益与韩国现有的预防RSVH的指南进行比较.
主要方法:
- 分析了IRST,包括与RSV季节相对的出生时间,家庭吸烟和兄弟姐妹/托儿所接触等因素.
- 一个13475名婴儿 (32-35 wGA) 的历史数据集被用来比较韩国指南和RSVH的IRST的预测准确性.
- 根据韩国参数调整的成本效益分析评估了以任何一种方法为指导的预防的成本效益.
主要成果:
- IRST确定了85.1%的RSVH,曲线下的面积为0.773,显著超过韩国指南 (26.9%和0.512).
- 与韩国指南 (29,674,102) 相比,IRST (26,265,142) 的质量调整寿命年增量成本 (QALY) 较低.
- 在支付意愿值时,IRST的成本效益概率 (70.8%) 比韩国指南 (67.0%) 高.
结论:
- 在韩国采用IRST增强了对RSVH的保护,对32-35 wGA出生的脆弱婴儿.
- 与目前的韩国指南相比,IRST在针对帕利维祖马布预防方面展示了更好的成本效益.
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