绘制线粒体动力学研究的演变图:对全球趋势和合作的文献分析分析
Fugang Huang1, Ke Sun2, Zexuan Wu3
1The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
概括
线粒体动力学研究显著增长,重点转向疾病角色. 了解这种平衡是未来疾病治疗的关键.
科学领域:
- 细胞生物学 细胞生物学
- 生物化学 生物化学
背景情况:
- 线粒体动力学,包括裂变和融合,维持线粒体网络的稳定性和功能.
- 线粒体动力学的不平衡与细胞功能障碍,氧化应激,炎症和亡有关.
- 了解线粒体动力学对于疾病发病和治疗干预至关重要.
研究的目的:
- 进行对研究趋势,协作网络和线粒体动力学主题演变的文献分析.
- 从2000年到2023年分析与线粒体动力学相关的出版物和引用.
主要方法:
- 使用科学网络核心集合 (WoSCC) 数据库进行图书统计分析.
- 使用VOSviewer和CiteSpace可视化和分析出版物,引文,合作和关键词趋势.
主要成果:
- 对332篇出版物的分析显示,中国和美国是主要的研究贡献者.
- 主要机构包括清迈大学和加利福尼亚理工学院 (Caltech).
- 研究重点已经从基本的线粒体功能演变为疾病角色,包括阿尔茨海默氏症和心血管疾病.
结论:
- 线粒体动力学研究正在扩大,越来越强调其在疾病机制中的作用.
- 对这些疾病联系的进一步探索有助于开发新的治疗策略.
相关概念视频
Drawing Free-body Diagrams: Rules
The first step in describing and analyzing most phenomena in physics involves the careful drawing of a free-body diagram. Free-body diagrams are useful in analyzing forces acting on an object or system, and are employed extensively in the study and application of Newton's laws of motion. The steps to draw a free-body diagram are listed below:
Force Vector along a Line
Quite often in three-dimensional statics problems, the direction of a force is specified by two points through which its line of action passes. Consider a three-dimensional static pole with a cable anchored to the ground.
Free-body Diagram
In mechanics, understanding the motion of objects is essential, and one tool that helps solve this problem is the free-body diagram. It is a simple but powerful graphical representation that succinctly represents all the forces acting on an object. A free-body diagram can represent a stationary or moving object, and is used in mechanics to explain the cause of an object's motion.
A free-body diagram transforms a complex problem into a simple representation, making it easy to understand the...
A free-body diagram transforms a complex problem into a simple representation, making it easy to understand the...
Relation Between the Distributed Load and Shear
Understanding the relationship between the distributed load and shear force in structural analysis is crucial for analyzing beams subjected to various loading conditions. Consider the case of a beam experiencing a distributed load, two concentrated loads, and a couple moment.
Coriolis Force
An accelerating particle experiences a force equal to the mass multiplied by the acceleration in an inertial frame of reference. Consider a particle in a non-inertial frame of reference, such as a sliding ball on a rotating table. The acceleration of the ball in this rotating reference frame is different than in the intertial frame, which modifies its equation of motion. The fictitious forces acting additionally on a rotating frame of reference alter Newton's Second Law expression. Centripetal...
Correlation of Experimental Data
Dimensional analysis simplifies complex physical problems and guides experimental investigations, but it does not provide complete solutions. It identifies the dimensionless groups that influence a phenomenon, but experimental data is needed to establish the specific relationships and validate theoretical predictions.
For example, a spherical particle moving through a viscous fluid experiences drag. Dimensional analysis shows that the drag force depends on the particle's diameter, velocity, and...
For example, a spherical particle moving through a viscous fluid experiences drag. Dimensional analysis shows that the drag force depends on the particle's diameter, velocity, and...


