mGem:在晚期艾滋病毒疾病的背景下,败血症和抗菌素耐药性
Rachel M Wake1,2, Nelesh P Govender1,2,3,4
1Wits Mycology Division, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, Gauteng, South Africa.
mBio
|April 11, 2025
概括
血流感染 (BSI) 的败血症显著增加了晚期艾滋病毒疾病 (AHD) 患者的死亡率. 有证据表明,在这个易受伤害的群体中,BSI风险,抗菌素耐药性和死亡率更高.
科学领域:
- 传染性疾病 传染性疾病
- 艾滋病毒 医学 艾滋病毒 医学
- 临界护理医学 临界护理医学
背景情况:
- 败血症,通常源于血流感染 (BSI),是晚期艾滋病毒疾病 (AHD) 患者的主要死亡原因.
- 在AHD患者中,BSI的特定发病率,原因和结果仍然不充分理解.
- 现有数据表明,BSI的易感性增加,包括由抗微生物药物耐药 (AMR) 生物体引起的,以及这一群体的死亡率增加.
研究的目的:
- 审查目前关于BSI在患有AHD的住院患者的发病率,病因和结局的证据.
- 要突出与AHD中BSI相关的风险和死亡率的增加.
- 识别知识缺口,并强调需要进一步研究.
主要方法:
- 一个全面的现有文献和证据,关于BSI在先进的艾滋病毒病患者的综合审查.
- 对与BSI相关的风险因素,致病原体和死亡率的数据进行分析.
- 综合发现,以定义当前的理解,并确定需要进一步调查的领域.
主要成果:
- 患有AHD的患者面临BSI的风险增加,抗微生物耐药 (AMR) 病原体的流行率显著.
- 与BSI相关的死亡率在AHD患者中明显高于其他人群.
- 导致BSI的已识别的病原体正在演变,可能受到抗逆转录病毒治疗覆盖率增加和全球AMR趋势的影响.
结论:
- 进一步的研究是必不可少的,以更好地定义BSI流行病学和AHD患者的结果.
- 在住院期间和之后开发和完善BSI预防和管理的干预措施至关重要.
- 需要有针对性的策略来降低AHD人群中与败血症相关的死亡率.
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