在健康人群中,运动强度,内皮功能和 ghrelin 的相互关系
Kara C Anderson1,2, Emily E Grammer1, Benjamin Stephenson1
1Department of Kinesiology, School of Education and Human Development, University of Virginia, Charlottesville, Virginia, USA.
Physiological reports
|April 11, 2025
概括
高强度运动显著改善内皮功能,并抑制林水平,无论是乙化还是脱化形式. 这些效应,特别是女性的 ghrelin 抑制,显示出与内皮功能改善的中等关系.
科学领域:
- 运动生理学 运动生理学
- 内分泌学 在内分泌学.
- 心血管健康 心血管健康
背景情况:
- 格林素以乙化 (AG) 和脱化 (DAG) 异型存在,可能会影响内皮功能 (EF).
- 急性炼会影响格林和EF,但炼强度的作用仍未得到充分研究.
研究的目的:
- 研究运动强度和性别对内皮功能和 ghrelin 水平的明显影响.
- 为了确定运动诱导的格林异型变化是否与内皮功能相关.
主要方法:
- 一个最大循环人体表测试确定了运动强度:中等 (MOD) 在乳酸值 (LT) 和高 (HIGH) 在75%的LT到VO2峰值差异.
- 参与者 (9名男性,8名女性) 接受了三个条件:CON (控制),MOD和HIGH运动.
- 运动前和运动后测量了内皮功能 (流介导扩张,口腔疾病) 和 ghrelin 水平 (AG,DAG).
主要成果:
- 无论是MOD还是HIGH运动强度都显著增加了口病.
- 高强度运动抑制了AG和DAG ghrelin异型体.
- 与MOD和CON相比,女性在HIGH后的DAG水平显著降低,口和胆固醇水平之间存在相关性.
结论:
- 高强度运动对于抑制 ghrelin 异型体和增强内皮功能至关重要.
- 格林抑制和内皮功能改善之间的关系似乎是微弱到中度的,在DAG格林中观察到性别特异性反应.
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