在长期成功治疗的艾滋病毒患者中,自主心血管控制受损
Thomas Adriaan Bouwmeester1,2, Iris A J van der Wulp3,4, Yaw A Kusi Mensah1,2
1Amsterdam UMC, University of Amsterdam, Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.
AIDS (London, England)
|April 11, 2025
概括
艾滋病毒感染的男性表现出自主心血管控制受损,由较低的巴罗反射灵敏度 (BRS) 和心率可变性 (HRV) 证明. 这可能会增加他们的心血管疾病风险,可能与抗逆转录病毒药物暴露有关.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 自主神经科学 自主神经科学
背景情况:
- 艾滋病毒感染者 (PLWH) 面临心血管疾病 (CVD) 风险升高.
- 在PLWH中持续的炎症和线粒体功能障碍可能会损害自主心血管控制.
- 降低腹反射灵敏度 (BRS) 和心率变化 (HRV) 是这种损伤的关键指标.
研究的目的:
- 为了比较艾滋病毒感染者和未感染者之间的交叉相关性BRS (xBRS) 和HRV.
- 调查艾滋病毒特异性因素与自主控制标志物之间的关联.
主要方法:
- 包括来自AGEhIV和HELIUS队伍的50-70岁的欧洲男性.
- 使用非侵入性连续血压监测测量了xBRS,SDNN和RMSSD.
- 采用调整为传统心血管疾病风险因素的回归模型.
主要成果:
- 与对照组相比,艾滋病毒感染的参与者表现出明显较低的xBRS,SDNN和RMSSD.
- 艾滋病毒的持续时间较长,先前使用的二氧化核化物和蒂米丁类似物与较低的xBRS相关.
- 纳迪尔 CD4 数量与SDNN积极相关; 蒂米丁模拟器持续时间与SDNN和RMSSD负面相关.
结论:
- 在HIV感染的男性中,自主心血管控制受损.
- 这种损伤可能与先前的抗逆转录病毒药物暴露和免疫缺陷有关.
- 自主控制受损可能导致PLWH观察到的心血管疾病风险增加.
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