口腔潜在恶性疾病和口腔状细胞癌的营养缺乏症
Shoa Shamsi1, Arpita Rai1, Lakhan Manjhi2
1Department of Oral Medicine and Radiology, Dental College, Rajendra Institute of Medical Sciences (RIMS), Bariatu, Ranchi, Jharkhand, India.
Journal of cancer research and therapeutics
|April 11, 2025
概括
包括维生素B12和叶酸在内的营养缺乏与口腔状细胞癌 (OSCC) 和口腔潜在恶性疾病 (OPMD) 有关. 评估这些缺陷可能有助于预测OSMF和OSCC患者的疾病进展.
科学领域:
- 口腔瘤学 在口腔瘤学.
- 营养生物化学 营养生物化学
- 癌症生物标志物 癌症生物标志物
背景情况:
- 口腔状细胞癌 (OSCC) 和口腔潜在恶性疾病 (OPMDs) 构成了重大的健康挑战.
- 口腔下粘膜纤维化 (OSMF),通常与白果的使用有关,是一种流行的OPMD,特别是在印度.
- 调查营养不足作为OSCC和OPMD的潜在早期标志物对于及时干预至关重要.
研究的目的:
- 评估OSMF和OSCC患者的维生素B12,叶酸和铁缺乏症.
- 评估这些营养标志物在指示疾病进展方面的潜力.
- 探索营养状况与口腔癌和癌前病变的发展之间的关系.
主要方法:
- 酶相关免疫吸收试验 (ELISA) 用于测量维生素B12和叶酸水平.
- 临床化学技术分析了血清铁和总铁结合能力 (TIBC).
- 统计分析比较了患者组和对照组之间的标记水平.
主要成果:
- 与健康对照组相比,OSCC和OSMF患者的维生素B12和叶酸水平显著降低.
- 血清铁的下降趋势被注意到,虽然不是统计学上显著的.
- 在研究组中观察到总铁结合能力 (TIBC) 的变化.
结论:
- 维生素B12,叶酸和铁缺乏与OSMF和OSCC有关,表明它们在疾病发病和进展中的作用.
- 这些缺陷可以作为诊断和管理OPMD和OSCC的有价值的预测指标.
- 需要进一步的研究来证实这些发现,并探索潜在的机制,如原体代谢和铁的利用.
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