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Updated: May 14, 2025

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Assessment of Kidney Function in Mouse Models of Glomerular Disease
Published on: June 30, 2018
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儿童和青少年COVID-19后的功能
Lu Li1,2, Ting Zhou1, Yiwen Lu1,2
1The Center for Health AI and Synthesis of Evidence, University of Pennsylvania, Philadelphia.
JAMA network open
|April 11, 2025
概括
COVID-19 感染增加了儿童和青少年长期脏问题的风险. 对于那些患有现有的病或急性损伤 (AKI) 的人来说,这种风险更高,这凸显了持续监测的必要性.
科学领域:
- 儿科脏病学 儿科脏病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 儿童群体中SARS-CoV-2感染对脏健康的长期影响在很大程度上是未知的.
- 了解这些风险对于管理儿童和青少年急性后COVID-19护理至关重要.
研究的目的:
- 为了确定SARS-CoV-2感染是否与儿童和青少年脏并发症风险增加有关.
- 评估这些风险在具有先前存在的病或急性损伤 (AKI) 的子组中.
主要方法:
- 一项回顾性队列研究,涉及19个美国卫生机构的超过190万名儿科患者.
- 利用了NIH RECOVER计划 (2020年3月 - 2023年5月) 的数据,比较了SARS-CoV-2阳性和阴性儿童之间的结果.
- 结局包括新发慢性病 (CKD) 和复合事件,分析使用Cox回归与倾向分数分层.
主要成果:
- 感染SARS-CoV-2与新发性CKD 2+阶段 (HR 1.17) 和CKD 3+阶段 (HR 1.35) 的风险显著增加.
- 在患有慢性病的儿童中,COVID-19增加了复合病事件的风险 (HR 1.15).
- 患有急性期AKI的儿科患者在感染后出现复合结局 (HR 1.29) 的风险增加.
结论:
- 在儿童和青少年中,SARS-CoV-2感染与急性脏后不良结果的风险增加有关.
- 对于那些先前患有脏疾病或先前患有AKI的人来说,风险特别高.
- 建议在SARS-CoV-2感染后对儿科患者进行警的长期脏监测.
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