海报会议:使用OPM-MEG研究人类对比差别歧视的时间过程
Abbie Lawton1, Richard Aveyard1, Alex Wade1
1University of York.
Journal of vision
|April 11, 2025
概括
研究人员将老鼠大脑任务适应人类,使用新型神经成像 (OPM-MEG) 来研究信息流. 人类行为反映了小鼠数据,OPM-MEG成功解码了任务元素,验证了其用于跨物种大脑研究的用途.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 计算生物学 计算生物学
背景情况:
- 国际大脑实验室 (IBL) 项目旨在在感知决策过程中绘制小鼠大脑范围信息流的地图.
- 了解 priors 如何调节这种信息流,对于描述神经计算至关重要.
- 将IBL范式转化为人类对于桥梁动物和人类神经科学至关重要.
研究的目的:
- 为了使IBL 2AFC任务适应人类受试者.
- 通过心理学和新型神经成像 (OPM-MEG) 来研究人类的行为反应和大脑活动.
- 为了比较人类和动物的行为数据,并与fMRI对OPM-MEG发现进行验证.
主要方法:
- 对人类参与者进行2个替代性强制选择 (2AFC) 感知决策任务的调整.
- 通过心理物理测试收集行为数据.
- 使用光学磁计 - 磁脑摄影 (OPM-MEG) 和功能磁共振成像 (fMRI) 获取神经成像数据.
主要成果:
- 人类的心理物理反应密切地复制了动物行为的关键特征,包括感知先验的影响 (偏见).
- 人类的心理反应功能表现出与小鼠观察到的类似的形式和偏见依赖.
- 磁脑电图数据允许时间解析的视觉刺激,反应,偏差和反的解码.
- OPM-MEG结果与使用相同范式获得的fMRI数据显示一致.
结论:
- 适应IBL任务适用于人类研究,允许直接比较动物数据.
- 光学磁计-磁大脑摄影 (OPM-MEG) 是人类IBL任务的可行神经成像技术.
- 多模式神经成像 (OPM-MEG和fMRI) 可以弥合动物神经元记录和人类全脑活动模式之间的差距.
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