患有腺病毒或呼吸道同胞性病毒住院后的慢性肺病
Tatjana Zaharov1, Kristina Træholt Franck2, Ulrikka Nygaard3,4
1From the Department for Children and Adolescents, Zeeland University Hospital, Nykobing F, Denmark.
The Pediatric infectious disease journal
|April 11, 2025
概括
患有腺病毒 (AdV) 或呼吸道同胞病毒 (RSV) 的住院增加了儿童患喘的风险. 在AdV感染后,没有证实间歇性肺病风险.
科学领域:
- 儿科肺病学 儿科肺病学
- 传染病 传染病 传染病
- 流行病学 流行病学
背景情况:
- 之前的研究表明,在腺病毒 (AdV) 住院后出现间歇性肺病 (ILD) 和呼吸道共病毒 (RSV) 住院后出现喘的风险很高.
- 在常见的儿童呼吸道感染之后的长期肺部后果需要进一步澄清.
研究的目的:
- 为了确定患有AdV或RSV感染住院的儿童肺部疾病发展的程度.
- 评估这些住院后的喘,支气管切除和ILD的长期风险.
主要方法:
- 采用了基于登记的队列研究设计.
- 来自4704名患有AdV或RSV住院儿童的数据与长期健康记录 (15-20年) 相关,用于诊断喘,支气管炎症,ILD和药物使用.
- 一个年龄匹配的对照组被用于计算随后的肺部疾病的危险比率 (HR).
主要成果:
- 在患有AdV或RSV的住院儿童中,没有观察到间歇性肺病或支气管切除症的显著增加.
- 发现了喘诊断或药物使用的显著风险:AdV为29%和65%,RSV为22%和51%.
- 与对照组相比,调整后的危险比率表明,在AdV和RSV住院后,喘风险明显增加.
结论:
- 该研究没有证实在腺病毒感染后出现间歇性肺病的风险增加.
- 在住院治疗腺病毒和呼吸道同胞病毒感染后,患喘的风险相当大.
- 在RSV住院后患喘的风险,尤其是药物使用所表明的风险,似乎比以前报告的更高.
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