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Updated: May 14, 2025

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干扰素调节因子4在多发性骨髓瘤细胞中介导非酶性IRE1依赖

Ioanna Oikonomidi1, Vasumathi Kameswaran2, Victoria C Pham2

  • 1Department of Research Oncology, Genentech, Inc., South San Francisco, California, United States of America.

PLoS biology
|April 11, 2025
PubMed
概括

多发性骨髓瘤细胞利用需要异醇的酶1 (IRE1) 进行生长. 研究人员发现,干扰素调节因子4 (IRF4) 中介IRE1对多发性髓瘤细胞循环进展的非酶效应.

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