患有儿科多发性硬化症患者的父母的儿童逆境
Kimberly A O'Neill1, Leigh Charvet1, Allan George1
1NYU Grossman School of Medicine, New York, NY.
Multiple sclerosis and related disorders
|April 11, 2025
概括
超过一半的儿童多发性硬化症 (MS) 的父母报告了不良童年经历 (ACE). 这凸显了代际逆境在儿童多发性硬化症发展中的潜在作用.
科学领域:
- 神经免疫学 神经免疫学
- 儿科神经学 儿科神经学
- 环境流行病学环境流行病学
背景情况:
- 儿童的环境因素,包括产前,可以影响多发性硬化症 (MS) 的风险.
- 童年时期的逆境会导致生物,行为和表观遗传的变化,可能会影响未来几代人.
- 在儿科多发性硬化症中,代际逆境的作用仍未得到充分研究.
研究的目的:
- 确定患有多发性硬化症的儿童父母中不良童年经历 (ACE) 的患病率和类型.
主要方法:
- 一项纵向研究招募了68名儿科多发性硬化症患者及其照顾者.
- 父母填写了10项关于他们自己的童年不良童年经历 (ACE) 问卷.
- 比较数据包括96名健康儿科对照的父母和全国成人队列.
主要成果:
- 超过50%的儿童多发性硬化症患者的父母报告至少有一次ACE.
- 父母报告的ACE包括虐待,忽视和家庭功能障碍.
- 超过10%的家长报告了高累积ACE得分 (≥7).
结论:
- 儿童时期的逆境在患有儿科MS的孩子的父母中很普遍.
- 需要进一步的研究来探索代际逆境对儿科发病性MS的影响.
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