探索 subthalamic 刺激对帕金森病中语义语言流性的局部和网络影响
Guangrui Zhao1,2, Yifeng Cheng2,3, Guangfeng Li2,3
1Departments of1Neurosurgery and.
Journal of neurosurgery
|April 11, 2025
概括
在帕金森病患者中,体下刺激可以降低口语流 (VF). 这种下降与刺激位置和前额叶皮层连接性减少有关,特别是在左侧.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 神经外科 神经外科
背景情况:
- 脑下垂体刺激是帕金森病的常见治疗方法.
- 口语流性 (VF) 的下降是已知的副作用,但其机制尚未完全理解.
研究的目的:
- 为了研究亚thalamic刺激对语义VF下降的影响.
- 分析与VF下降相关的因素,并探索潜在的机制.
- 检查刺激对VF的局部和网络效应.
主要方法:
- 研究了78名帕金森病患者,根据刺激后的VF变化分为稳定和下降的组.
- 基线和随访临床概况的比较.
- 使用组织活化量 (VTA) 构建了局部和网络效应模型.
主要成果:
- 语义VF下降与Hoehn和Yahr阶段和特定刺激坐标相关 (左侧X和Y).
- 摩托子体内核的VTA覆盖面对VF产生了负面影响.
- 与VF下降相关的刺激部位更接近运动改善的最佳部位.
- 纤维过和网络分析显示,前额叶皮层连接性下降,特别是背侧前额叶皮层,与VF下降有关.
结论:
- 亚thalamic刺激导致语义VF的下降.
- 静脉缩受术后疾病严重程度和刺激效应的影响.
- 观察到的VF下降是横向的,主要影响左半球.
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