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Updated: May 14, 2025

Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors
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质子感知和激活一个检测质子的GPCR

Li-Nan Chen1, Hui Zhou1, Kun Xi1

  • 1Department of Pathology of Sir Run Run Shaw Hospital, Department of Pharmacology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China.

Molecular cell
|April 11, 2025
PubMed
概括

像人类的GPR4一样的质子感应G蛋白合受体 (GPCR) 使用histidine残留物来检测酸度. 这引发了结构变化,揭示了这些关键受体如何激活以及药物如何向它们.

关键词:
在ECL2中使用ECL2.在 GPR4 中使用.在NE52-QQ57之间.激活机制的激活机制形状变换的变化是指形状的变化.低温电磁波冷却器 (Cryo-EM) 是一个非常好的方法.具有质子感应的GPCRR.

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