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Updated: May 20, 2025

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在多臂多阶段设计中的高效阶段性分配比率

Ruqayya A Azher1, Michael J Grayling2, James M S Wason3

  • 1Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK; Medical College, Umm Al-Qura University, Makkah, Saudi Arabia.

Contemporary clinical trials
|April 11, 2025
PubMed
概括

在多臂多阶段 (MAMS) 试验中优化分配比率可以提高统计能力. 将这些比率调整为特定的试验目标,如边际,断层或连接力,可以提高药物开发中的决策和资源效率.

关键词:
适应性设计适应性设计群组顺序 顺序 的 组.过渡期分析 中间分析响应适应性 响应适应性两个阶段的两个阶段.

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