克罗托克辛调节Encephalitozoon cuniculi感染的巨细胞向M1杀菌特征进行调节
Cristina Gabriela Nascimento de Oliveira1, Anuska Marcelino Alvares-Saraiva1, Elizabeth Cristina Perez1
1Programa de Patologia Ambiental e Experimental da Universidade Paulista-Unip, São Paulo, Brazil.
概括
毒素 (CTX) 没有杀死Encephalitozoon cuniculi子. 然而,CTX增强了对显微体的巨细胞活性,增加了M1概况和促炎性细胞因子的产生.
科学领域:
- 免疫学 免疫学 免疫学
- 寄生虫学的寄生虫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 微菌是一种机遇性细胞内真菌,对常规药物有抗性.
- 微菌可以通过将M1巨细胞转移到M2形状来逃避巨细胞的杀菌活性.
- 来自Crotalus durissus terrificus的毒素 (CTX) 具有抗菌,抗瘤和抗炎性质.
研究的目的:
- 评估CTX对Encephalitozoon cuniculi子生存能力的影响.
- 评估CTX对感染E. cuniculi的巨细胞的杀菌活性的影响.
主要方法:
- 用CTX (2.4和4.8μg/mL) 处理E. cuniculi子进行生存分析.
- 小鼠腹膜巨细胞被E. cuniculi感染,并用CTX.治疗.
- 评估了巨细胞的形状,细胞因子的产生 (TNF-α,IL-6) 和子的增殖.
主要成果:
- CTX对E. cuniculi子没有直接的杀菌或菌效应.
- CTX治疗 (2.4μg/mL) 增加了受感染细胞中的M1巨体概况.
- CTX在受感染的巨细胞中增强了缩,增加了TNF-α和IL-6的产生,减少了子的增殖.
结论:
- CTX可以调节巨细胞M1特征,防止E. cuniculi感染.
- CTX增强了促炎性细胞因子的产生,从而增加了杀菌活性.
- CTX显示出作为抗微杆菌病的免疫调节剂的潜力.
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