在患有慢性脏病和肝炎的患者中,住院皮下注射富洛塞米德:一个质量改进项目
Ella Tumelty1, Rosa Montero1, Ashwin Anenden2
1St George's University Hospitals NHS Foundation Trust, London, England, UK.
BMJ open quality
|April 11, 2025
概括
在家用皮下注射的罗塞米德有效地治疗慢性病和心力衰竭 (CKD-HF) 患者的液体过载. 这种多学科的方法避免了符合条件的患者入院,证明是可行的和受欢迎的.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
背景情况:
- 患有心力衰竭和慢性病 (CKD-HF) 的患者经常因流体过载而入院.
- 这一患者群经常经历虚弱和经常性住院,造成重大成本.
- 需要有效的管理策略来减少医疗负担并改善患者的治疗结果.
研究的目的:
- 评估在CKD-HF患者的家庭皮下富罗塞米德治疗液体过载的可行性.
- 评估这种多学科,以社区为基础的干预措施的安全性和有效性.
- 为了确定这种方法是否可以减少住院的数量.
主要方法:
- 设计了一个概念验证,多学科的质量改进项目.
- 患有CKD-HF和液体过载的患者在家中每天接受80mg皮下罗西米德,持续5天.
- 治疗由医院在家团队与远程监测进行,并每天对功能和体重进行评估.
主要成果:
- 10名患者完成了家庭治疗,在5天的干预期内避免住院治疗.
- 没有观察到功能或水平的显著变化.
- 一名患者在复查后入院,两名患者在完成治疗后入院;没有出现重大安全问题.
结论:
- 在家用皮下注射furosemide的管理在CKD-HF患者中管理流体过载是从逻辑上可行的.
- 这种干预,在初级保健合作的支持下,有可能减少住院治疗.
- 这种方法受到患者的好评,表明它是住院护理的有希望的替代方案.
相关概念视频
Heart Failure Drugs: Diuretics
295
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
295
Renal Failure: Dose Adjustments
37
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
37
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
321
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
321
Factors Affecting Renal Clearance: Renal Impairment
35
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
35
Dialysis
233
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
233
Heart Failure Drugs: Inotropic Agents
426
Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
426


