[APA对老年肉患者功能表现的影响]
Matthieu Lilamand1, Théodore Decaix2, Fanny Chatenet2
1Hôpital Lariboisière - Fernand-Widal, AP-HP Nord, université Paris Cité, 200 rue du Faubourg-Saint-Denis, 75010 Paris, France; Inserm UMR-S 1144, université Paris Cité, 4 avenue de l'Observatoire, 75006 Paris, France.
Soins. Gerontologie
|April 11, 2025
概括
适应体力活动,包括电路健身房训练,显著改善了老年人的功能表现. 这项为期三个月的计划增强了运动和力量,为与年龄相关的肌肉损失提供了至关重要的干预措施.
科学领域:
- 老年学是指老年学的学科.
- 运动生理学 运动生理学
- 康复科学 康复科学 康复科学
背景情况:
- 麻症,与年龄相关的肌肉损失,显著影响老年人的功能独立性.
- 适应性体力活动 (APA) 对于预防和治疗肉症至关重要.
- 多元组件炼计划在缓解功能衰退方面表现有前途.
研究的目的:
- 评估一种新的"电路健身房"计划在老年人身上对功能性表现的影响.
- 为了评估一个三个月的干预组合耐力,机器阻力和平衡练习的有效性.
- 为了确定专业的高级设计的阻力机器是否提高了结果.
主要方法:
- 一个单一中心,为期三个月的干预研究,涉及95名老年患者 (平均年龄82.5岁,59%为女性).
- "电路健身房"计划整合了耐力训练,机器阻力练习和平衡练习.
- 功能性能的测量是使用短物理性能电池 (SPPB),步行速度,椅子提升测试,和定时上升和去 (TUG) 测试.
主要成果:
- 在SPPB得分中,统计学上显著的中位数增加了两点 (p<0.0001).
- 在行走速度,椅子提升性能和TUG测试时间方面观察到显著的改善.
- 多组件APA计划在三个月内显示出明显的功能益处.
结论:
- 多组件适应的体育活动,特别是"电路健身房"计划,有效地改善了老年人患有肉症的功能表现.
- 该干预提供了一种可行的策略,用于打击功能衰退,并提高脆弱老年人群的流动性.
- 这项研究强调了有针对性的运动干预措施在治疗与年龄相关的肉症中的重要性.
相关概念视频
Drug Dosing: Geriatric Patients
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Pharmacodynamics in Geriatric Patients: Effects of Age
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...


