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Updated: May 23, 2025

Experimental Quantification of Interactions Between Drug Delivery Systems and Cells In Vitro: A Guide for Preclinical Nanomedicine Evaluation
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种群药动力学模型中的间偶变性:可识别性,影响性,相互依赖性和衍生研究设计建议

Emily Behrens1, Sebastian G Wicha2

  • 1Department of Clinical Pharmacy, Institute of Pharmacy, University of Hamburg, Bundesstraße 45, 20146, Hamburg, Germany.

Journal of pharmacokinetics and pharmacodynamics
|April 11, 2025
PubMed
概括

在稀疏的药理动力学研究中建模间场变性 (IOV) 是复杂的. 这种模拟发现,包括更多的场合和低谷样本可以改善参数估计和IOV检测,这对于准确的临床试验设计至关重要.

关键词:
偶尔间的变化性 偶尔间的变化性这就是NONMEM®.药物指标 (Pharmacometrics) 是一个指标.随机模拟和估计 随机模拟和估计研究设计研究设计.

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