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Updated: May 14, 2025

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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通过内核膜酸酶复合体抑制TGF-β/SMAD信号传递

Zhe Ji1, Wing-Yan Skyla Siu1, Maria Emilia Dueñas2,3

  • 1Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.

Nature communications
|April 11, 2025
PubMed
概括

转化生长因子-β (TGF-β) 信号通过核内受体调节的SMADs (R-SMADs) 的脱酸化被禁用. 一个MAN1-CTDNEP1-NEP1R1复合体调解了这一关键的R-SMAD失活.

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