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Updated: May 14, 2025

Functional Characterization of RING-Type E3 Ubiquitin Ligases In Vitro and In Planta
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在TRIM蛋白家族中的RING E3伪酶的鉴定

Jane Dudley-Fraser1, Diego Esposito1, Katherine A McPhie1

  • 1Molecular Structure of Cell Signalling Laboratory, The Francis Crick Institute, London, UK.

Nature communications
|April 11, 2025
PubMed
概括

一些TRIpartite Motif (TRIM) 蛋白质作为伪酶起作用,由于其RING域的结构变化,缺乏全方位素E3酶活性. 这一发现影响了对TRIM蛋白在细胞过程和疾病中的功能的理解.

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