和多基基物质对有饮用水暴露史的人影响甲状腺激素
Taylor S Noyes1, Laura M Abington1, T Joost van 't Erve1
1Michigan Department of Health and Human Services, Environmental Health Bureau, 333 South Grand Ave., 3rd Floor, Lansing, MI, 48909, USA.
Scientific reports
|April 11, 2025
概括
这项研究发现,暴露于和多基基物质 (PFAS) 混合物与青少年和成人甲状腺激素水平降低有关,特别是三甲状腺激素 (TT3). 这些发现凸显了PFAS混合物对甲状腺健康的潜在风险.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
背景情况:
- 和多醇基物质 (PFAS) 是广泛存在的环境污染物.
- 证据将PFAS暴露与甲状腺激素干扰联系在一起是混合的.
- 酸混合物对甲状腺激素的影响尚不清楚.
研究的目的:
- 研究血清PFAS度 (单个和混合) 与甲状腺激素水平之间的关联.
- 检查线性和非线性关系.
- 为了利用密歇根PFAS暴露和健康研究队列的数据.
主要方法:
- 从728名青少年和成年人的血清样本中分析了39种PFAS和4种甲状腺激素.
- 统计方法包括线性回归,加权定量和 (WQS) 回归,主要组件分析 (PCA) 和贝叶斯核机器回归 (BKMR).
- 分析评估了单个PFAS和PFAS混合物与甲状腺激素度之间的关联.
主要成果:
- 个人分析显示,PFUnA与TT3.3降低有关.
- 所有三种混合物分析 (WQS,PCA,BKMR) 均一致表明PFAS混合物与TT3.3之间的反向关系.
- 在PFAS混合物中,一个标准偏差的增加与TT3度下降1.2%至2.0%有关.
结论:
- 在血清PFAS混合物和甲状腺激素失调之间观察到横断关联.
- 观察到的主要效应是血清TT3度的降低.
- 这项研究有助于了解PFAS混合物对甲状腺功能的复杂影响.
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