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Huanli Zhang¹, Zhen Zhang²

¹Department of Geriatrics, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250033, China.

Scientific reports

|April 11, 2025

概括

暴露于乙烯氧化物 (EO) 与克洛托水平有负相关性,克洛托是一种抗衰老激素. 这项研究发现了一种非线性关系,表明EO暴露对健康的潜在影响.

科学领域:

环境健康环境健康
生物化学生化学
老年学是指老年学的学科.

背景情况:

乙烯氧化物 (EO) 是一种工业化学品和消毒剂,广泛使用.
克洛托是一种抗衰老激素,参与各种生理过程.
在EO暴露和klotho水平之间的关联是不确定的.

研究的目的:

为了研究乙烯氧化物 (EO) 暴露和血清中克洛托水平之间的关系.
为了确定EO暴露是否与成年人中克洛托水平的变化有关.

主要方法:

从NHANES 2013-2016年对1696名成年人 (40-79岁) 的回顾性横截面研究.
通过EO (HbEO) 的血红蛋白添加剂评估的乙烯氧化物暴露.
在血液样本中测量Klotho水平;统计分析包括线性回归和曲线拟合.

主要成果:

在对混因子进行调整后,在log2HbEO和klotho水平之间观察到显著的负相关性 (β=-17.29,P=0.002).
与最低五分位数 (β=-70.79,P=0.007) 相比,EO暴露的最高五分位数显示了显著较低的克洛托水平.
在log2HbEO和klotho水平之间确定了一个反向的"L形"非线性关系 (P为非线性=0.04).

结论:

乙烯氧化物暴露与klotho水平负面且非线性相关.
这一发现表明,环境中EO暴露与与衰老相关的生物标志物之间存在潜在的生物联系.
需要进一步的研究来确认因果关系并阐明潜在的机制.

关键词:

横截面研究横截面研究乙烯氧化物乙烯氧化物克洛托 (Klotho) 是一个古老的语言.尼汉斯 (NHANES) 是一个名人.美国成年人美国成年人

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