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乳头振荡失律症和被破坏的功能连接在乳头皮层环在围产中风中的功能循环
Anton Rogachov1, Helen L Carlson2,3, Amanda Robertson1,4
1Division of Neurology, The Hospital for Sick Children, University of Toronto, 175 Elizabeth Street | 19th floor, Toronto, ON, M5G 2G3, Canada.
Scientific reports
|April 11, 2025
概括
在儿童中,周心室静脉梗塞 (PVI) 与大脑活动的改变有关,特别是区域振荡活动的增加和胸膜皮层途径的破坏. 这些变化与运动障碍相关,为PVI提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 儿科神经学 儿科神经学
背景情况:
- 周心室静脉梗塞 (PVI) 是一种围产中风的亚型,在妊娠34周之前影响皮下白质.
- PVI与终身运动障碍和降低生活质量有关.
- 与PVI相关的运动缺陷背后的神经生物学机制仍然不太清楚.
研究的目的:
- 调查PVI儿童运动障碍的神经生物学基础.
- 为了分析区域和跨网络的连接中断在丘脑,基底和皮质.
- 探索PVI中大脑功能和临床运动结果之间的关系.
主要方法:
- 休息状态功能磁共振成像 (fMRI) 用于患有PVI (n=23) 和典型发育儿童 (TDC,n=22) 的儿童.
- 分析了功能指标,包括低频波动幅度 (ALFF),分数ALFF,区域同质性 (ReHo),集中度 (DC) 和功能连接性 (FC).
- 分析的重点是区域振荡活动和thalamocortical干扰.
主要成果:
- 与TDC相比,患有PVI的儿童呈现出明显更高的ALFF.
- 在PVI中较高的ALFF水平与较大的运动障碍严重程度有关.
- 患有PVI的儿童的丘脑在丘脑皮层路径中的连接性降低,特别是与中部前额叶皮层 (mPFC) 的连接性降低.
结论:
- 沙lamus中区域振荡活动的增加可能会扰乱PVI儿童的沙lamus皮层网络连接.
- 这些干扰与PVI儿童观察到的运动障碍有关.
- 这些发现突出显示了在围产中风后的运动发育中,甲状腺皮层通路完整性的作用.
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