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Updated: Jun 28, 2026

Dopamine Release at Individual Presynaptic Terminals Visualized with FFNs
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一种模块化点击连接体导向的方法来标记活细胞中的内源性多巴胺D受体

Xavier Gómez-Santacana1,2, Marin Boutonnet3, Carles Martínez-Juvés4

  • 1Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS and INSERM, Montpellier, France. xavier.gomez@iqac.csic.es.

Communications chemistry
|April 11, 2025
PubMed
概括

研究人员开发了新的光探针来标记本地G蛋白结合受体 (GPCRs),而无需进行遗传修饰. 这种方法可以监测其自然细胞环境中的内源GPCRs,从而推进药理学研究.

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Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
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