一项流行率研究,重点关注住院的COPD相关的肺高血压
Ting-Chia Chang1,2, Ching-Min Wang3, Chung-Han Ho4,5
1Department of Internal Medicine, College of Medicine, Chi-Mei Medical Center, Tainan, Taiwan.
Scientific reports
|April 11, 2025
概括
慢性阻塞性肺病 (COPD) 患者的肺高血压显著增加死亡风险. 尽管患病率下降趋势,但COPD相关的肺高血压的早期检测和干预至关重要.
科学领域:
- 肺部医学 肺部医学
- 流行病学 流行病学
- 心脏病学 心脏病学
背景情况:
- 肺高血压 (PH) 是慢性阻塞性肺病 (COPD) 患者死亡的一个重要因素.
- 目前关于COPD相关PH患病率的流行病学数据有限,导致不一致的估计.
- 了解COPD相关PH的患病率和影响对于患者管理至关重要.
研究的目的:
- 评估在被诊断患有COPD的个人中PH的患病率.
- 评估COPD相关PH对短期和长期死亡率的影响.
- 确定与COPD相关PH的患病率相关的因素.
主要方法:
- 利用台湾国家医疗保险数据库 (2009-2018) 的医疗索赔数据.
- 鉴定了40岁以上的患有COPD诊断的患者,将指数日期定义为首次COPD住院.
- 按性别,年龄和COPD严重程度分层的PH患病率;与PH和没有PH的COPD患者之间的死亡率进行比较.
主要成果:
- 在215,292例COPD住院病例中,确定了与COPD相关的PH平均患病率为每1000人中39.9.
- 患病率在男性每年下降,但在女性保持稳定;较高的COPD严重程度与增加的PH患病率相关.
- 与没有PH的患者相比,患有PH的COPD患者在一年,三年和五年内死亡率显著更高.
结论:
- 尽管出现下降趋势,但与COPD相关的PH仍然与COPD严重程度密切相关.
- 患有PH的COPD患者面临着大幅增加的死亡风险.
- 优先考虑与COPD相关的PH的早期检测和干预对于改善患者的治疗结果至关重要.
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